S-methyl Methanethiosulfonate: Promising Late Blight Inhibitor or Broad Range Toxin?
Identifieur interne : 000067 ( Main/Exploration ); précédent : 000066; suivant : 000068S-methyl Methanethiosulfonate: Promising Late Blight Inhibitor or Broad Range Toxin?
Auteurs : Charlotte Joller [Suisse] ; Mout De Vrieze [Suisse] ; Aboubakr Moradi [Suisse] ; Claudine Fournier [Suisse] ; Delphine Chinchilla [Suisse] ; Floriane L'Haridon [Suisse] ; Sebastien Bruisson [Suisse] ; Laure Weisskopf [Suisse]Source :
- Pathogens (Basel, Switzerland) [ 2076-0817 ] ; 2020.
Abstract
(1) Background: S-methyl methanethiosulfonate (MMTS), a sulfur containing volatile organic compound produced by plants and bacterial species, has recently been described to be an efficient anti-oomycete agent with promising perspectives for the control of the devastating potato late blight disease caused by Phytophthora infestans. However, earlier work raised questions regarding the putative toxicity of this compound. To assess the suitability of MMTS for late blight control in the field, the present study thus aimed at evaluating the effect of MMTS on a wide range of non-target organisms in comparison to P. infestans. (2) Methods: To this end, we exposed P. infestans, as well as different pathogenic and non-pathogenic fungi, bacteria, the nematode Caenorhabditis elegans as well as the plant Arabidopsis thaliana to MMTS treatment and evaluated their response by means of in vitro assays. (3) Results: Our results showed that fungi (both mycelium and spores) tolerated MMTS better than the oomycete P. infestans, but that the compound nevertheless exhibited non-negligible toxic effects on bacteria, nematodes and plants. (4) Conclusions: We discuss the mode of action of MMTS and conclude that even though this compound might be too toxic for chemical application in the field, its strong anti-oomycete activity could still be exploited when naturally released at the site of infection by plant-associated microbes inoculated as biocontrol agents.
DOI: 10.3390/pathogens9060496
PubMed: 32580401
PubMed Central: PMC7350374
Affiliations:
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xml:lang="en">S-methyl Methanethiosulfonate: Promising Late Blight Inhibitor or Broad Range Toxin?</title><author><name sortKey="Joller, Charlotte" sort="Joller, Charlotte" uniqKey="Joller C" first="Charlotte" last="Joller">Charlotte Joller</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biology, University of Fribourg, 1702 Fribourg</wicri:regionArea><orgName type="university">Université de Fribourg</orgName><placeName><settlement type="city">Fribourg</settlement><region nuts="3" type="region">Canton de Fribourg</region></placeName></affiliation></author><author><name sortKey="De Vrieze, Mout" sort="De Vrieze, Mout" uniqKey="De Vrieze M" first="Mout" last="De Vrieze">Mout De Vrieze</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biology, University of Fribourg, 1702 Fribourg</wicri:regionArea><orgName type="university">Université de Fribourg</orgName><placeName><settlement type="city">Fribourg</settlement><region nuts="3" type="region">Canton de Fribourg</region></placeName></affiliation></author><author><name sortKey="Moradi, Aboubakr" sort="Moradi, Aboubakr" uniqKey="Moradi A" first="Aboubakr" last="Moradi">Aboubakr Moradi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biology, University of Fribourg, 1702 Fribourg</wicri:regionArea><orgName type="university">Université de Fribourg</orgName><placeName><settlement type="city">Fribourg</settlement><region nuts="3" type="region">Canton de Fribourg</region></placeName></affiliation></author><author><name sortKey="Fournier, Claudine" sort="Fournier, Claudine" uniqKey="Fournier C" first="Claudine" last="Fournier">Claudine Fournier</name><affiliation wicri:level="4"><nlm:affiliation>Medical and Molecular Microbiology, University of Fribourg, 1702 Fribourg, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical and Molecular Microbiology, University of Fribourg, 1702 Fribourg</wicri:regionArea><orgName type="university">Université de Fribourg</orgName><placeName><settlement type="city">Fribourg</settlement><region nuts="3" type="region">Canton de Fribourg</region></placeName></affiliation></author><author><name sortKey="Chinchilla, Delphine" sort="Chinchilla, Delphine" uniqKey="Chinchilla D" first="Delphine" last="Chinchilla">Delphine Chinchilla</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biology, University of Fribourg, 1702 Fribourg</wicri:regionArea><orgName type="university">Université de Fribourg</orgName><placeName><settlement type="city">Fribourg</settlement><region nuts="3" type="region">Canton de Fribourg</region></placeName></affiliation></author><author><name sortKey="L Haridon, Floriane" sort="L Haridon, Floriane" uniqKey="L Haridon F" first="Floriane" last="L'Haridon">Floriane L'Haridon</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biology, University of Fribourg, 1702 Fribourg</wicri:regionArea><orgName type="university">Université de Fribourg</orgName><placeName><settlement type="city">Fribourg</settlement><region nuts="3" type="region">Canton de Fribourg</region></placeName></affiliation></author><author><name sortKey="Bruisson, Sebastien" sort="Bruisson, Sebastien" uniqKey="Bruisson S" first="Sebastien" last="Bruisson">Sebastien Bruisson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biology, University of Fribourg, 1702 Fribourg</wicri:regionArea><orgName type="university">Université de Fribourg</orgName><placeName><settlement type="city">Fribourg</settlement><region nuts="3" type="region">Canton de Fribourg</region></placeName></affiliation></author><author><name sortKey="Weisskopf, Laure" sort="Weisskopf, Laure" uniqKey="Weisskopf L" first="Laure" last="Weisskopf">Laure Weisskopf</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biology, University of Fribourg, 1702 Fribourg</wicri:regionArea><orgName type="university">Université de Fribourg</orgName><placeName><settlement type="city">Fribourg</settlement><region nuts="3" type="region">Canton de Fribourg</region></placeName></affiliation></author></analytic><series><title level="j">Pathogens (Basel, Switzerland)</title><idno type="ISSN">2076-0817</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">(1) Background: S-methyl methanethiosulfonate (MMTS), a sulfur containing volatile organic compound produced by plants and bacterial species, has recently been described to be an efficient anti-oomycete agent with promising perspectives for the control of the devastating potato late blight disease caused by <i>Phytophthora infestans.</i> However, earlier work raised questions regarding the putative toxicity of this compound. To assess the suitability of MMTS for late blight control in the field, the present study thus aimed at evaluating the effect of MMTS on a wide range of non-target organisms in comparison to <i>P. infestans</i>. (2) Methods: To this end, we exposed <i>P. infestans,</i> as well as different pathogenic and non-pathogenic fungi, bacteria, the nematode <i>Caenorhabditis elegans</i> as well as the plant <i>Arabidopsis thaliana</i> to MMTS treatment and evaluated their response by means of in vitro assays. (3) Results: Our results showed that fungi (both mycelium and spores) tolerated MMTS better than the oomycete <i>P. infestans,</i> but that the compound nevertheless exhibited non-negligible toxic effects on bacteria, nematodes and plants. (4) Conclusions: We discuss the mode of action of MMTS and conclude that even though this compound might be too toxic for chemical application in the field, its strong anti-oomycete activity could still be exploited when naturally released at the site of infection by plant-associated microbes inoculated as biocontrol agents.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32580401</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2076-0817</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><Issue>6</Issue><PubDate><Year>2020</Year><Month>Jun</Month><Day>22</Day></PubDate></JournalIssue><Title>Pathogens (Basel, Switzerland)</Title><ISOAbbreviation>Pathogens</ISOAbbreviation></Journal><ArticleTitle>S-methyl Methanethiosulfonate: Promising Late Blight Inhibitor or Broad Range Toxin?</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E496</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/pathogens9060496</ELocationID><Abstract><AbstractText>(1) Background: S-methyl methanethiosulfonate (MMTS), a sulfur containing volatile organic compound produced by plants and bacterial species, has recently been described to be an efficient anti-oomycete agent with promising perspectives for the control of the devastating potato late blight disease caused by <i>Phytophthora infestans.</i> However, earlier work raised questions regarding the putative toxicity of this compound. To assess the suitability of MMTS for late blight control in the field, the present study thus aimed at evaluating the effect of MMTS on a wide range of non-target organisms in comparison to <i>P. infestans</i>. (2) Methods: To this end, we exposed <i>P. infestans,</i> as well as different pathogenic and non-pathogenic fungi, bacteria, the nematode <i>Caenorhabditis elegans</i> as well as the plant <i>Arabidopsis thaliana</i> to MMTS treatment and evaluated their response by means of in vitro assays. (3) Results: Our results showed that fungi (both mycelium and spores) tolerated MMTS better than the oomycete <i>P. infestans,</i> but that the compound nevertheless exhibited non-negligible toxic effects on bacteria, nematodes and plants. (4) Conclusions: We discuss the mode of action of MMTS and conclude that even though this compound might be too toxic for chemical application in the field, its strong anti-oomycete activity could still be exploited when naturally released at the site of infection by plant-associated microbes inoculated as biocontrol agents.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Joller</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Vrieze</LastName><ForeName>Mout</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-7295-2495</Identifier><AffiliationInfo><Affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moradi</LastName><ForeName>Aboubakr</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fournier</LastName><ForeName>Claudine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Medical and Molecular Microbiology, University of Fribourg, 1702 Fribourg, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chinchilla</LastName><ForeName>Delphine</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>L'Haridon</LastName><ForeName>Floriane</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruisson</LastName><ForeName>Sebastien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weisskopf</LastName><ForeName>Laure</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Fribourg, 1702 Fribourg, Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>31003A_179310, 316030_177093</GrantID><Agency>Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Pathogens</MedlineTA><NlmUniqueID>101596317</NlmUniqueID><ISSNLinking>2076-0817</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Keywords: bacterial volatiles</Keyword><Keyword MajorTopicYN="N">MMTS</Keyword><Keyword MajorTopicYN="N">Phytophthora infestans</Keyword><Keyword MajorTopicYN="N">biofungicide</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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sort="De Vrieze, Mout" uniqKey="De Vrieze M" first="Mout" last="De Vrieze">Mout De Vrieze</name><name sortKey="Fournier, Claudine" sort="Fournier, Claudine" uniqKey="Fournier C" first="Claudine" last="Fournier">Claudine Fournier</name><name sortKey="L Haridon, Floriane" sort="L Haridon, Floriane" uniqKey="L Haridon F" first="Floriane" last="L'Haridon">Floriane L'Haridon</name><name sortKey="Moradi, Aboubakr" sort="Moradi, Aboubakr" uniqKey="Moradi A" first="Aboubakr" last="Moradi">Aboubakr Moradi</name><name sortKey="Weisskopf, Laure" sort="Weisskopf, Laure" uniqKey="Weisskopf L" first="Laure" last="Weisskopf">Laure Weisskopf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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